Even though Fleet Admiral Akainu stands at the top of the Marine hierarchy, there are multiple Devil Fruits that pose a threat to his reign.
Roronoa Zoro hasn't eaten any Devil Fruit, but if he did, he should consider the best fruits for his skills—such as Onigumo's or the More-More Fruit.
Admiral Garp is one of the powerful characters in One Piece, and Devil Fruits like the Press-Press and Twinkle-Twinkle would make him even stronger.
Some fans think Skypiea is a skippable arc, but the mysteries, reveals and comedic moments make it a very enjoyable one that everyone can appreciate.